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E-Health Intervention for Cancer Survivors 2.0

Phase 1
19 Years
Open (Enrolling)

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Trial Information

E-Health Intervention for Cancer Survivors 2.0

Nearly 65% of those with cancer diagnoses will survive for at least 5 years, with
approximately 10.5 million cancer survivors in the United States. The time of transition for
cancer patients, from active treatment to survivorship, has been identified as a time of
high risk for depression and anxiety. Cancer survivors experience higher rates of anxiety
and depression than those without a cancer history. Research has identified fear of
recurrence, perceived loss of support, and social pressure to resume a "normal" life, among
other phenomena, as sources for this emotional distress. However, only about 20% of all
patients referred for psychotherapy ever enter treatment and of those who initiate
treatment, nearly half drop out before completion. This suggests that there are significant
barriers to receiving care. These barriers may be even higher for cancer survivors
struggling with issues related to re-entry, such as returning to work, resuming household
responsibilities and managing residual symptoms such as fatigue or pain.

The internet promises to provide inexpensive access to treatment at any time of the day or
night. Unfortunately, the potential for internet delivered services has not been realized.
Studies examining treatments that simply provide access to an internet site commonly result
in very high dropout after the first site visit, and typically little or no improvement
target symptoms. A variety of methods to improve responses to internet interventions have
been examined. In general, e-mail support improves adherence and telephone support can
improve adherence even more. Another type of support that has only begun to be investigated
is the use of social networks to help maintain adherence.

This intervention will use an online social network, to increase adherence and promote the
use of the website and the skills it teaches.

Inclusion Criteria:

- Any cancer diagnosis.

- Has completed treatment for cancer and is currently in full remission.

- ECOG performance Status of < 3.

- Has a telephone, e-mail account, computer, and broadband access to the Internet.

- Has familiarity with using the Internet that allows for adequate navigation of

- Is able to speak and read English.

- Is at least 19 years of age.

- Is able to give informed consent.

Exclusion Criteria:

- Has visual impairment that would prevent use of the website and completion of
assessment materials.

- Diagnosis of basal or squamous cell skin cancers.

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Depression, as measured by the Hospital Anxiety and Depression Scale (HADS)

Outcome Time Frame:

Measured at baseline, 4 weeks, 8 weeks and 12 weeks

Safety Issue:


Principal Investigator

David C. Mohr, Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Northwestern University


United States: Institutional Review Board

Study ID:

NU Lurie 10CC01



Start Date:

May 2011

Completion Date:

November 2013

Related Keywords:

  • Cancer
  • cancer
  • cancer survivors
  • internet
  • depression
  • anxiety



Northwestern UniversityChicago, Illinois  60611