Human Papillomavirus (HPV) Oral Transmission Study in Partners Over Time
This study evaluates oral HPV infection and risk factors in people with head and neck cancer
and their partners or spouses. The study focuses on oropharyngeal cancer patients and
includes patients with HPV-associated and HPV-unassociated disease. A comparison group of
people without cancer (controls) are also being enrolled. Couples are followed
longitudinally and there is a repository of study samples. It is hoped that this research
will help us understand risk factors for oral HPV infection, persistence and transmission as
well as researching biomarkers for HPV-associated oral cancer and survival.
The study is led by Dr Amber D'Souza (Johns Hopkins) and laboratory testing for the study is
performed in the laboratory of study co-investigator Dr Maura Gillison (Ohio University).
The study biorepository is led by Dr karen Anderson (Arizona State). Participants are being
enrolled at four sites across the United States including: Mt Sinai (site PI Dr Marshall
Posner), Johns Hopkins (site PI Dr Sara Pai), Dana Farber Cancer Institute (site PI Dr
Robert Haddad) and Oregon Health and Science University (site PI Dr Neil Gross).
Observational Model: Cohort, Time Perspective: Prospective
HPV DNA detection in oral rinse sample
Detection of 17 types of HPV DNA in exfoliated oral cells of cases and partners collected using an oral rinse and gargle
Gypsyamber D'Souza, PhD
Johns Hopkins Bloomberg School of Public Health
United States: Institutional Review Board
|Oregon Health & Science University||Portland, Oregon 97201|
|Dana Farber Cancer Institute||Boston, Massachusetts 02115|
|Johns Hopkins Hospital||Baltimore, Maryland 21287|
|Mt Sinai School of Medicine||New York, New York 10029|