Genetics and Biology of Liver Tumorigenesis in Children
- To identify biomarker signatures associated with hepatoblastoma subtypes (by microRNA
array profiling), and their potential correlation with liver developmental stages as
well as outcome.
- To correlate expression array data with copy number array data.
- To carry out a focused sequencing interrogation of amplified or deleted genomic regions
as well as genes in key cell pathways involved in embryonic development and/or stem
cell signaling pathways for which preliminary data suggests involvement in the
pathogenesis of hepatoblastoma.
- To perform whole exome sequencing in a subset of tumors.
OUTLINE: This is a multicenter study.
Archived tumor tissue samples are analyzed for hepatoblastoma and other liver tumor
biomarkers by microRNA array profiling and exome sequencing. Results are then compared with
patients' clinical data.
Biomarkers associated with hepatoblastoma subtypes and cancer stages
Gail E. Tomlinson, MD, PhD
University of Texas Health Science Center at San Antonio