Know Cancer

or
forgot password

Genetics and Biology of Liver Tumorigenesis in Children


N/A
N/A
16 Years
Not Enrolling
Both
Liver Cancer

Thank you

Trial Information

Genetics and Biology of Liver Tumorigenesis in Children


OBJECTIVES:

Primary

- To identify biomarker signatures associated with hepatoblastoma subtypes (by microRNA
array profiling), and their potential correlation with liver developmental stages as
well as outcome.

- To correlate expression array data with copy number array data.

Secondary

- To carry out a focused sequencing interrogation of amplified or deleted genomic regions
as well as genes in key cell pathways involved in embryonic development and/or stem
cell signaling pathways for which preliminary data suggests involvement in the
pathogenesis of hepatoblastoma.

- To perform whole exome sequencing in a subset of tumors.

OUTLINE: This is a multicenter study.

Archived tumor tissue samples are analyzed for hepatoblastoma and other liver tumor
biomarkers by microRNA array profiling and exome sequencing. Results are then compared with
patients' clinical data.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of hepatoblastoma or other liver cancer including the following subtypes:

- Pure fetal histology

- Transitional histology

- Small cell undifferentiated histology

- Participated on the Children's Oncology Group (COG) clinical trials

- Available data and tumor samples

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Biomarkers associated with hepatoblastoma subtypes and cancer stages

Safety Issue:

No

Principal Investigator

Gail E. Tomlinson, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Texas Health Science Center at San Antonio

Authority:

Unspecified

Study ID:

CDR0000698720

NCT ID:

NCT01336881

Start Date:

June 2011

Completion Date:

Related Keywords:

  • Liver Cancer
  • childhood hepatoblastoma
  • stage I childhood liver cancer
  • stage II childhood liver cancer
  • stage III childhood liver cancer
  • stage IV childhood liver cancer
  • Liver Neoplasms

Name

Location