Inclusion Criteria

Inclusion Criteria for patients with chemotherapy :

- Patient(e) aged over 65 years

- Non metastatic breast cancer

- Adjuvant chemotherapy Breast cancer: FEC, including Docetaxel Protocols

- No major cognitive impairment

- Lack of personality disorders and psychiatric disorders evolutionary

- Having signed the informed consent of study participation

Inclusion Criteria for patients without chemotherapy (control group):

- Patient(e) aged over 65 years

- Breast cancer

- Patients receiving no adjuvant chemotherapy

- No major cognitive impairment

- Lack of personality disorders and psychiatric disorders evolutionary

- Having signed the informed consent of study participation

- Matching on age, sex, cultural level and tumor location

Exclusion Criteria for patients with chemotherapy :

- Metastatic

- Cancer primitive other than breast

- Patients under 65 years

- Patients with adjuvant chemotherapy is associated with targeted therapy

- Patients who have received other cancer treatments (chemotherapy or radiotherapy
brain)

- disorders of higher functions existing in the administration of chemotherapy

- Pathology psychiatric evolutionary

- Refusal of participation

- Patients unable to meet the cognitive tests

- Drug use

- Heavy drinking