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Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Wave 3

34 Years
69 Years
Open (Enrolling)
HTN, Diabetes, Heart Disease, Cancer, Alzheimer's Disease

Thank you

Trial Information

Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Wave 3

The Healthy Aging in Neighborhoods of Diversity across the Life Span study (HANDLS) is a
multidisciplinary, community-based, prospective longitudinal epidemiologic study examining
the influences of race and socioeconomic status (SES) on the development of age-related
health disparities among socioeconomically diverse African Americans and whites in
Baltimore. This study investigates whether health disparities develop or persist due to
differences in SES, differences in race, or their interaction. This study is unique because
it will assess over a 20-year period physical parameters as well as evaluate genetic,
biologic, demographic, and psychosocial parameters of African American and white
participants in higher and lower SES. It also employs novel research tools, mobile medical
research vehicles, in hopes of improving participation rates and retention among
non-traditional research participants. The domains of the HANDLS study include: nutrition,
cognition, biologic biomarkers, body composition and bone quality, physical function and
performance, sociodemographics, psychosocial, neighborhood environment and cardiovascular
disease. Utilizing data from these study domains will facilitate understand the driving
factors behind persistent black-white health disparities in overall longevity,
cardiovascular disease, and cognitive decline.

HANDLS Wave 1, the initial recruitment and examination phase that began in August 2004, is
complete. The current protocol outlines the revisit waves of this study HANDLS Wave, 2
entitled, The Association of Personality and Socioeconomic status with Health Status - An
Interim Follow-up Study, which began in June 2006 under a separate protocol is designed as a
telephone interview to occur approximately 18 months after the first visit to the mobile
Medical Research Vehicles (MRVs). Wave 2 provides interim contact with study participants,
and important interim information regarding their health. The next visit HANDLS Wave 3 will
consist of the second visit to the mobile Medical Research Vehicles (MRVs) for a health
examination to occur at least 3 years after the first, a telephone interview to include the
dietary interview and questionnaires, and for a random sample of those who participate in
the revisit a direct measurement of renal function and a brain scan study using M RI to
examine the structure of the brain.

Inclusion Criteria


Verified HANDLS participants

Able to give informed consent

Must have valid picture identification



Within 6 months of active treatment of Cancer (Chemotherapy, biologic, radiation)

Type of Study:


Study Design:

Time Perspective: Prospective

Principal Investigator

Michele K Evans, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Institute on Aging (NIA)


United States: Federal Government

Study ID:




Start Date:

June 2009

Completion Date:

Related Keywords:

  • HTN
  • Diabetes
  • Heart Disease
  • Cancer
  • Alzheimer's Disease
  • Health Disparities
  • Diversity
  • Socioeconomic Status
  • Epidemiology
  • Alzheimer Disease
  • Heart Diseases



National Institute of Aging, Clinical Research Unit Baltimore, Maryland  21224