Inclusion Criteria:

- Signed informed consent

- Histologically confirmed colorectal cancer

- Age 18-70 years old

- Advanced colorectal cancer patients, first-line or second-line treatment, the
adjuvant treatment including the oxaliplatin or/and 5FU should be finished six months
before

- Have at least one measurable lesion according to the Response Evaluation Criteria in
Solid Tumors (RECIST) criteria.

- ECOG 0-1

- Life expectancy of more than 3 months.

- Normal laboratory values: hemoglobin > 90g/dl, neutrophils > 1.5×10^9/L, platelets >
100×10^9/L, serum creatinine < 1.5×upper limit of normal (ULN), serum bilirubin <
1.5×ULN, ALT and AST < 2.5×ULN, AKP < 4×ULN

Exclusion Criteria:

- Pregnant or lactating patients

- Concurrent disease or condition that would make the subject inappropriate for study
participation, or any serious medical disorder that would interfere with the
subject's safety

- Active or uncontrolled infection

- Known history of uncontrolled or symptomatic angina, arrhythmias, or congestive heart
failure

- Patients could not swallow the tablets

- Concomitant with brain metastases