Ex Vivo Multimodal Imaging of Upper Aerodigestive Epithelium
The overall objective of this exploratory study is to evaluate whether noninvasive
fluorescence and reflectance imaging of the upper aerodigestive tract can help clinicians
more accurately determine intraoperative margins during ablative cancer surgery. This is an
ex vivo study designed to evaluate the feasibility of using prototype optical imaging
technology to enhance the discrimination between areas of noncancerous "normal" and
cancerous mucosa. The results of this laboratory study will be used to further refine and
develop this technology for in vivo application.
(1) To collect data to develop imaging algorithms to distinguish between normal and
cancerous upper aerodigestive mucosa.
1. To compare the combination of wide-field fluorescence/reflectance and high resolution
fluorescence microscopy images of upper aerodigestive epithelium to histopathologic
analysis of biopsied tissue.
2. To compare the ability of sequential wide-field/fluorescence microscopy imaging to
discriminate between normal and cancerous oral cavity mucosa with that of white-light
images obtained after staining with toluidine blue.
Observational Model: Case-Only, Time Perspective: Cross-Sectional
Accuracy and Interrater Reliability of HRME Image Interpretation
We will ask blinded raters to classify the HRME images as either benign (normal) or dysplastic/cancerous (abnormal)
Andrew Sikora, MD, PhD
Mount Sinai School of Medicine
United States: Institutional Review Board
GCO # 09-0945
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