Comparison of Creatinine Clearance Calculation Methods for Estimation of Glomerular Filtration Rate in Patients Receiving High-Dose Methotrexate
We intend to perform a retrospective chart review to identify a serum creatinine-based
equation that gives the best estimate of CrCl as compared with an equation derived from a
24-hour urine collection.
Study subjects will be identified using the Brigham and Women's Hospital and Dana-Farber
Cancer Institute's Adult Pharmacy systems to identify patients who received high-dose
methotrexate. Data will be collected starting with December 31, 2010 and proceeding
chronologically backwards until the target enrollment of 40 patients is reached.
Observational Model: Cohort, Time Perspective: Retrospective
To identify a serum creatinine-based equation that gives the best estimate of CrCl as compared to a measured creatinine clearance formula.
Serum creatinine-based equations to be included in that analysis are: Cockcroft-Gault with the following weight descriptors; ideal body weight, actual body weight, and adjusted body weight; Modified MDRD; CKD-EPI.
Audrea H Szabatura, PharmD, BCOP
Dana-Farber Cancer Institute
United States: Institutional Review Board
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