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Effects of Topical Dexpanthenol on Chemotherapy and Radiotherapy Induced Oral Mucositis

Phase 2
Open (Enrolling)
Oral Mucositis (Ulcerative) Due to Radiation

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Trial Information

Effects of Topical Dexpanthenol on Chemotherapy and Radiotherapy Induced Oral Mucositis

Patients will be given a bottle of 5% Dexpanthenol mouthwash and they are asked to rinse 10
ml of it three times a day. At the onset of mucositis and then for 4 subsequent weeks they
will be examined to evaluate the condition of their oral mucosa.By the advent of mucositis
stage 4 ,at any time during the 4 weeks of study,the patient would be out.if any patient
shows allergic reaction to dexpanthenol,he/she would be out of study too.

Inclusion Criteria:

1. without any systemic disease

2. estimated survival of at least 6 months

3. without any mental disorders

4. grade 1 to 3 WHO mucositis

Exclusion Criteria:

1. development of grade 4 WHO mucositis

2. Brachytherapy

3. allergy to the drug

4. dissatisfaction of the patient

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Outcome Measure:

reduction of intensity of mucositis

Outcome Description:

measuring of the intensity of mucositis by visual examination and asking the patient about pain and discomfort

Outcome Time Frame:

first week (week one)

Safety Issue:


Principal Investigator

Fahimeh Anbari, resident

Investigator Role:

Principal Investigator

Investigator Affiliation:

dental faculty of shaheed Beheshti medical university


Iran: Ministry of Health

Study ID:




Start Date:

September 2010

Completion Date:

September 2011

Related Keywords:

  • Oral Mucositis (Ulcerative) Due to Radiation
  • Dexpanthenol
  • Radiotherapy
  • chemotherapy
  • Mucositis
  • Stomatitis
  • Ulcer
  • Mucositis