Inclusion Criteria:

1. Male or female cancer patients 20 years of age or older

2. Cancer related pain that requires treatment with continuous around-the-clock strong
opioid analgesic

3. Moderate to severe pain intensity(NRS pain score 4)

4. Opioid naïve patients or patients not treated with strong opioids(except PRN) within
4 weeks or patients who has been on weak opioids

5. Subject who provide signed and dated written voluntary informed consent

Exclusion Criteria:

1. Women of child-bearing potential, defined as all women physiologically capable of
becoming pregnant. UNLESS they are:

- women whose career, lifestyle, or sexual orientation precludes intercourse with
a male partner

- women shoes partners have been sterilized by vasectomy or other means

- two birth control methods. The two methods can be a double barrier method or a
barrier method plus a hormonal method. Adequate barrier methods of contraception
include: diaphragm, condom (by the partner), intrauterine device (copper or
hormonal), sponge or spermicide. Hormonal contraceptives include any marketed
contraceptive agent that includes an estrogen and/or a progestational agent.

2. Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a
female after conception and until the termination of gestation, confirmed by a
positive urine pregnancy test.

3. Have previously received treatment with Targin or Oxycontin within 4weeks(28days) of
screening periods(including PRN)

4. If subjects started first cycle of chemotherapy during the 2 weeks before the
screening visit or during the study, they should be excluded from the study.

And If the chemotherapy regimen or dosage to be planned to change during the study,
the subjects should be excluded from the study.

5. Patient who is administered laxatives with stable dose for more than 1 week

6. Patient with evidence of significant structural/functional abnormalities of GI tract
which is not appropriate for oral medicine administration. Any history of
hypersensitivity to Oxycodone and Naloxone

7. Patients with significant respiratory depression

8. Patients with acute or severe bronchial asthma or hypercarbia

9. Any patient who has or is suspected of having paralytic ileus

10. Severe Chronic obstructive pulmonary disease, pulmonary heart disease

11. Targin product contains lactose. Patients with rare hereditary problems of galactose
intolerance, Lapp lactase deficiency or glucose-galactose malabsorption should not
take

12. Patients with moderate and severe hepatic impairment

13. Abnormal aspartate aminotransferase (AST; SGOT), alanine aminotransferase (ALT;
SGPT), or alkaline phosphatase levels (>2.5 times the upper limit of normal, it is
allowed >5 times the upper limit of normal in case of transition in liver) or an
abnormal total bilirubin and/or creatinine level(s) (greater than 1.5 times the upper
limit of normal)

14. Any situation where opioids are contraindicated

15. Major surgery within 1 month prior to screening or planned surgery

16. Mainly pain originated other than cancer or cancer related conditions (eg.
Musculoskeletal pain, inflammatory pain, diabetic polyneuropathy)

17. Patients with known or suspected unstable brain metastases or spinal cord compression
that may require changes in steroid treatment throughout the duration of the study

18. Patients with uncontrolled seizures

19. Requiring interventional treatment for pain such as neurodestructive procedure or
regional infusion

20. With a history of alcohol abuse within 6 months of screening

21. With a history of illicit drug abuse within 6 months of screening

22. Patients with increased intracranial pressure

23. In the investigator's opinion, subjects who are receiving hypnotics or other central
nervous system (CNS) depressants that may pose a risk of additional CNS depression
with opioid study medication

24. Patients with myxodema, not adequately treated hypothyroidism or Addison's disease

25. Patients receiving opioid substitution therapy for opioid addiction (e.g. methadone
or buprenorphine)

26. Patients with evidence of clinically significant gastrointestinal disease (e.g.
paralytic ileus, peritoneal carcinosis), significant structural abnormalities of the
gastrointestinal tract (e.g. scarring, obstruction etc) either related or not related
to the underlying cancer or disease progression

27. Patients suffering from diarrhea and/or opioid withdrawal

28. With a disability that may prevent the patient from completing all study requirements
and in particular, interfere with 24hrs pain intensity score

29. Clinically significant impairment of cardiovascular, respiratory and renal function

30. Patient who needs acute dose titration or whose pain intensity fluctuate
significantly in a short period according to investigator's judgment

31. Having used other investigational drugs at the time of enrollment, or within 30 days
or 5 half-lives of enrollment, whichever is longer