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Relationship of Subcutaneous Adipose Tissue With HOMA-IR and Plasma Adiponectin Levels in Cases With Polycystic Ovarian Syndrome


N/A
18 Years
42 Years
Not Enrolling
Female
Polycystic Ovary Syndrome

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Trial Information

Relationship of Subcutaneous Adipose Tissue With HOMA-IR and Plasma Adiponectin Levels in Cases With Polycystic Ovarian Syndrome


Fifty-two patients with PCOS and fifty-tree healthy controls who were matched for body mass
index (BMI) and age (p=0.430, p=0.112, respectively) were enrolled in the study. Biceps,
triceps, subscapular and suprailiac skinfold thicknesses (SFT) of all cases were measured
via caliper device; mid-upper arm circumference (MUAC) via a tape; and body fat
distributions via a bioelectrical impedance device. Insulin resistance was calculated via
HOMA-IR while ELISA was used to measure plasma adiponectin.


Inclusion Criteria:



- All of the women with PCOS had normal thyroid-stimulating hormone and prolactin (PRL)
levels.

Exclusion Criteria:

- Subjects with possible ovarian tumors, congenital adrenal hyperplasia, BMI greater
than 35 kg/m2, any chronic renal or liver disease, were excluded from the study.

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Relationship of Subcutaneous Adipose Tissue with HOMA-IR and Plasma Adiponectin Levels in Cases with Polycystic Ovarian Syndrome

Outcome Description:

PCOS patients (the experimental group) had higher mean SFT values in all parts, mid-upper arm circumference values, whole body and trunk fat free mass amounts (FFM) and HOMA-IR values, while a lower adiponectin level.

Outcome Time Frame:

2 year

Safety Issue:

Yes

Principal Investigator

Aydogan Aydogdu, MD

Investigator Role:

Study Director

Investigator Affiliation:

Gulhane School of Medicine

Authority:

Turkey: Ministry of Health

Study ID:

27.04.2010/1491-764-10

NCT ID:

NCT01310569

Start Date:

January 2009

Completion Date:

August 2010

Related Keywords:

  • Polycystic Ovary Syndrome
  • PCOS, Skinfold thickness, HOMA-IR
  • Polycystic Ovary Syndrome

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