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A Phase 3, Multi-Site, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of The Efficacy And Safety Of 2 Oral Doses Of CP-690,550 In Subjects With Moderate To Severe Chronic Plaque Psoriasis

Phase 3
18 Years
Not Enrolling

Thank you

Trial Information

A Phase 3, Multi-Site, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of The Efficacy And Safety Of 2 Oral Doses Of CP-690,550 In Subjects With Moderate To Severe Chronic Plaque Psoriasis

Inclusion Criteria:

- 18 years or older with diagnosis for at least 12 months of moderate to severe plaque
psoriasis covering at least 10% of body surface area

- A Psoriasis Area and Severity Index (PASI) score of 12 or greater

- Are considered to be candidates for systemic or light therapy

- Have no evidence of active or latent tuberculosis

Exclusion Criteria:

- Non-plaque or drug-induced forms of psoriasis

- Cannot discontinue current oral, injectible or topical therapy for psoriasis or
cannot discontinue phototherapy (PUVA or UVB)

- Any uncontrolled significant medical condition

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

Physician's Global Assessment (PGA)response, ie, the proportion of participants achieving a PGA of "clear" or "almost clear" at week 16

Outcome Time Frame:

week 16

Safety Issue:


Principal Investigator

Pfizer Call Center

Investigator Role:

Study Director

Investigator Affiliation:



United States: Food and Drug Administration

Study ID:




Start Date:

March 2011

Completion Date:

April 2013

Related Keywords:

  • Psoriasis
  • chronic
  • severe
  • moderate
  • treatment
  • safety
  • efficacy
  • CP-690,550
  • Plaque Psoriasis
  • Psoriasis Vulgaris
  • Psoriasis



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Wake Forest University Health Sciences Winston-Salem, North Carolina  27157
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Somerset Skin Centre - Dermcenter Troy, Michigan  48084
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Dartmouth Hitchcock Medical Center - Section of Dermatology Lebanon, New Hampshire  03756
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