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Pilot Study to Evaluate In Vivo Plastic Scintillation Detectors for Real-Time Radiation Dosimetry During Prostate Cancer Radiotherapy

Phase 1
18 Years
Open (Enrolling)
Prostate Disease

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Trial Information

Pilot Study to Evaluate In Vivo Plastic Scintillation Detectors for Real-Time Radiation Dosimetry During Prostate Cancer Radiotherapy

As a part of your standard of care, you will have external beam radiation therapy. You will
have a computerized tomography (CT) scan of the pelvis before the external beam radiation

For the CT scan, you will be given an enema to empty your bowel, and you will drink about 16
to 24 ounces of water to fill your bladder

A rectal balloon will then be inserted into your rectum and filled with either air or water.
You will then have the CT scan. The CT scan should take about 45 minutes.

If you agree to take part in this study, very thin (millimeter-sized) radiation detectors
will be attached to the rectal balloon during each of two CT scans per week you will have
while you are receiving radiation. You may have additional CT scans (without the detector)
each week if your doctor thinks it is needed.

The doses read by the radiation detectors will be compared to the doses that you were
originally scheduled to receive after each radiation treatment and at the end of the study.

You will be off study after your final radiation treatment using the rectal balloon.

This is an investigational study. Up to 10 patients will take part in this study. All will
be enrolled at MD Anderson.

Inclusion Criteria:

1. Any patients with prostate cancer who are undergoing routine radiation therapy for
their prostate cancer, including post-prostatectomy patients.

2. The selection criteria will be limited to the patient's ability to withstand
insertion of a rectal balloon and his willingness to participate in the study.

3. We will choose patients undergoing photon and proton treatments.

Exclusion Criteria:

Type of Study:


Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Measurement of True In Vivo Radiation to Rectal Wall During Prostate Radiotherapy

Outcome Description:

Twice a week in vivo measurements of radiation dose absorbed by the rectal wall during intensity-modulated radiotherapy (IMRT) of prostate.

Outcome Time Frame:

Twice a week for 7 week treatment.

Safety Issue:


Principal Investigator

Sam Beddar, PHD

Investigator Role:

Principal Investigator

Investigator Affiliation:

UT MD Anderson Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

November 2011

Completion Date:

Related Keywords:

  • Prostate Disease
  • Fiber optic radiation detectors
  • Enhanced endorectal balloon
  • Radiation treatment
  • Radiotherapy
  • External beam radiation
  • Dosimetry
  • Prostatic Diseases
  • Prostatic Neoplasms



UT MD Anderson Cancer CenterHouston, Texas  77030