Effect of Remote Ischemic Preconditioning on Lung Injury in Patients Undergoing Pulmonary Lobectomy:a Randomised Controlled Trial
Remote ischemic preconditioning is an intervention in which brief ischemia of one tissue or
organ protects remote organs from a sustained episode of ischemia. It is known that one-lung
ventilation in patients undergoing pulmonary lobectomy, which may cause acute lung injury.
The investigators did a single-blinded randomised controlled study to establish whether
remote ischemic preconditioning reduces lung injury in these patients.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Prevention
Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing pulmonary lobectomy
Compared with the control group, patients in the LRIP group had significantly higher Cs and Cd , along with lower PA-aDO2 and RI at various phase (P<0.05). Serum concentration of IL-6,IL-8, TNF-ɑ and MDA in LRIP group were decreased significantly at postoperative time points compared with those in control group (P<0.05), but SOD was increased significantly at the same time (P<0.05).
Xuan Ke Liu, Ph.d
Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University
China: Ethics Committee