Inclusion Criteria:

- Age of 18years or over

- Patients who had failed more than 1 cycle of standard therapy with advanced or
metastatic stage and with measurable lesions

- Life expectancy >/= 5 months

- Not available to any of resectable surgery or radiotherapy

- Patients with adequate organ(e.g. heart, kidney, liver)and bone marrow function, as
defined by

1. Absolute neutrophil count >/= 1.0 x 10^9/L, Platelet count >/= 75 x 10^9/L

2. Total bilirubin < 2.0 mg/dL

3. Aspartate Aminotransferase and/or Aspartate Aminotransferase < 5 x Upper Limit
Normal

4. creatinine < 2 x Upper Limit Normal

- ECOG status 0 to 2

- Female volunteers admitted to the study must be using a reliable means of
contraception and must have a negative blood or urine pregnancy test at least 7days
ago

- Patients or their legal representatives who have signed the informed consent form.

Exclusion Criteria:

- Have inflammatory bowel diseases

- Have severe diarrhea or ileus

- Previous total colectomy

- Have ileostomy

- Known brain or spinal cord metastases

- Patients who have received chemotherapy within the previous 4 weeks

- Patients who have received radiotherapy related tp colorectal cancer within 4weeks

- Patients who have participated in other clinical study within the previous 4weeks

- Pregnancy or lactation period

- Human Immunodeficiency Virus antibody (+)

- Have active infection or serious concomitant systemic disorder incompatible with the
study

- Clinically hypertension or diabetes mellitus not well controlled with medication

- Clinically significant cardiac disease(congestive heart failure, symptomatic coronary
artery disease and cardiac arrhythmias) or myocardial infarction

- Presence or history of malignancy other than colorectal cancer within 5years

- Have severe Neurologic or psychological disorder

- Patients who have history of allergy with this investigational drug(SB injection)

- Obvious cognitive or physical impairment that would prevent participation