Inclusion Criteria:

- Age of 18-70 years

- Patients with histologically or cytologically confirmed Non-Small Cell Lung Cancer

- Patients who had failed more than 1 cycle of standard therapy with advanced or
metasatic stage not available to any of resectable surgery or radiotherapy.

- Patients with measurable lesions

- Eatern Cooperative Oncolgy Group status 0 to 2.

- Life expectancy >/= 5 months

- Patients with adequate organ(heart, kidney, liver)and bone marrow function, as
defined by

1. Absolute neutrophil count >/= 1.5 x 10^9/L, Platelet count >/= 100 x 10^9/L

2. Total bilirubin
3. Aspartate Aminotransferase and/or Alanine Aminotransferase of normal

4. creatinine
- Patients who have signed the informed consent form.

Exclusion Criteria:

- Female volunteers admitted to the study must be using a reliable means of
contraception

- Received radiation therapy within 6 weeks before randomization

- Known brain or spinal cord metastases

- Have acute infection

- Have active infection or serious concomitant systemic disorder incompatible with the
study

- Presence or history of malignancy other than Non-Small Cell Lung Cancer

- Have severe neurologic or psychological disorder

- Patients who have to receive other chemo-radiotherapy or immunotherapy

- Patients who have received chemotherapy within the previous 30 days

- Patients who are candidates for combined modality treatment.

- Patients who have participated in a clinical study within the previous 30 days