Trial Information

Human Papillomatosis Genotyping and Severity in Patients With Recurrent Respiratory Papillomatosis of Children in Thailand

Recurrent respiratory papillomatosis is caused by human papilloma virus and is the most
common benign laryngeal neoplasm in children. Although RRP is rarely fatal, the disease
requires prolonged, extensive medical and surgical treatment, and causes physical and
emotional suffering in affected children and their families. Although recurrent respiratory
papillomatosis is a relatively unusual problem, it accounts for significant health are
expenditures.The goal of management of RRP is control of the disease, preservation of the
voice and prevention of major complication .The purpose of study will identify risk factors
for more severe juvenile RRP through prospective evaluation of a pediatric population in
Thailand by the employing a protocol that includes staging of disease severity , as well as
HPV genotyping.

Objective:

- To identify the genotypes of HPV isolated from Thai RRP patients

- To compare staging and severity with HPV genotypes

- To correlate the following characteristics of the Thai RRP patients with the HPV
genotypes