Recipient

Inclusion Criteria:

- 1. Understand and voluntarily sign an informed consent form.

- 2. Age 18-70 years at the time of signing the informed consent form.

- 3. Able to adhere to the study visit schedule and other protocol requirements.

- 4. Previously documented multiple myeloma (MM) with measurable monoclonal protein by
either serum/urine protein electrophoresis or serum free light chains, or measurable
plasmacytomas.

- 5. ECOG performance status of 0-2 at study entry (see Appendix 2).

- 6. Acceptable organ function as outlined in the protocol.

- 7. Otherwise fitting institutional criteria for allogeneic stem cell transplantation.

- 8. Presence of an HLA-matched (5/6 or 6/6 matched for HLA-A, B, and DR) sibling
donor, or a HLA-matched (matched for at least HLA-A, B, C, and DRB1) unrelated donor
by high-resolution testing.

- 9. Disease free of prior malignancies for >/= 5 years with exception of currently
treated basal cell, squamous cell carcinoma of the skin, or carcinoma "insitu" of the
cervix or breast.

- 10. All study participants must be registered into the mandatory RevAssist® program,
and be willing and able to comply with the requirements of RevAssist®.

- 11. Females of childbearing potential (FCBP) must have a negative serum or urine
pregnancy test

Recipient Exclusion Criteria:

- 1. Any serious medical condition, laboratory abnormality, or psychiatric illness that
would prevent the subject from signing the informed consent form.

- 2. Pregnant or breast feeding females.

- 3. Any condition, including the presence of laboratory abnormalities, which places
the subject at unacceptable risk if he/she were to participate in the study or
confounds the ability to interpret data from the study.

- 4. Known hypersensitivity to thalidomide or Lenalidomide.

- 5. The development of erythema nodosum if characterized by a desquamating rash while
taking thalidomide or similar drugs.

- 6. Known seropositive for or active viral infection with human immunodeficiency virus
(HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV). Patients who are
seropositive because of hepatitis B virus vaccine or prior infection to which they
are now immune (i.e., not carriers) are eligible.

Donor

Inclusion Criteria:

The following categories of donor will be acceptable:

- 1. HLA-matched related donor (5/6 or 6/6 match): Minimal typing necessary is
serologic typing for class I (A, B) and molecular typing for class II (DRB1).

- 2. HLA-matched Unrelated Donor (MUD): Molecular identity at least at HLA A, B, C, and
DRB1 and DQB1 (8/10 match) by high resolution typing is required.

- 3. Syngeneic donors are not eligible.

- 4. The donor must be healthy and must be an acceptable donor as per institutional
standards for marrow or stem cell donation.

- 5. Age ≥ 18 years