Inclusion Criteria:

- Diagnosis of multiple myeloma based on standard criteria as follows:

Major Criteria

- Plasmacytomas on tissue biopsy

- Bone marrow plasmacytosis (> 30% plasma cells)

- Monoclonal immunoglobulin (Ig) spike on serum electrophoresis (IgG > 3.5 g/dL or IgA
> 2.0 g/dL); kappa or lambda light chain excretion > 1 g/day on 24 hour urine protein
electrophoresis

Minor Criteria

- Bone marrow plasmacytosis (10 to 30% plasma cells)

- Monoclonal immunoglobulin present but of lesser magnitude than given under major
criteria

- Normal IgM < 50 mg/dL, IgA < 100 mg/dL, or IgG < 600 mg/dL

Any of the following sets of criteria will confirm the diagnosis of Multiple Myeloma:

- Any two of the major criteria

- Major criterion 1 plus minor criterion b, c

- Major criterion 3 plus minor criterion a or c

- Minor criteria a, b and c

- Measurable disease, defined as a monoclonal immunoglobulin spike on serum
electrophoresis of ≥ 1 g/dL and/or urine monoclonal immunoglobulin spike of ≥
200 mg/24 hours.

- Non-secretors must have measurable protein by Freelite or measurable disease
such as plasmacytoma to be eligible.

- Has asymptomatic disease, i.e., does not have hypercalcemia, renal
insufficiency, anemia or bone lesions.

- Karnofsky performance status ≥ 80 (See Appendix B)

- Is infertile (i.e. surgically sterile or 12 months post-menopausal) or is
practicing an adequate form of contraception, as judged by the investigator
(i.e., birth control pills, double barrier method, abstinence, etc.)

- Age 18 years or older

- Has given voluntary written informed consent, prior to any study-related
procedure not part of normal medical care, with the understanding that the
patient may withdraw consent at any time without prejudice to future medical
care.

Exclusion Criteria:

- Prior treatment for myeloma (symptomatic or asymptomatic).

- POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly,
endocrinopathy, monoclonal protein (M-protein) and skin changes)

- Plasma cell leukemia

- Patients with a history of thyroid problems.

- Receiving steroids > the equivalent of 10 mg prednisone daily for other medical
conditions, e.g., asthma, systemic lupus erythematosis, rheumatoid arthritis

- Infection not controlled by antibiotics

- Human Immunodeficiency Virus (HIV) infection. Patients should provide consent for HIV
testing according to the institution's standard practice

- Known active hepatitis B or C

- New York Hospital Association (NYHA) Class III or IV heart failure or EKG evidence of
acute ischemic disease

- Second malignancy requiring treatment in last 3 years

- Other serious medical or psychiatric illness that could potentially interfere with
the completion of treatment according to this protocol

- Positive pregnancy test in women of childbearing potential