Adherence to Medication and Its Impact on COPD Exacerbations: The AMICE Prospective Study
Inclusion Criteria:
- Clinical diagnosis of COPD
- Age > 40 years old
- Documented spirometry within the last 12 months with a post-bronchodilator FEV1 <
80% of predicted and an FEV1 < 70% of FVC (4 puffs of salbutamol 30 minutes prior to
spirometry)
- Patients being hospitalized for an exacerbation at the University Hospitals of Leuven
at time of enrollment
- Patients currently treated with Spiriva for at least 4 weeks at the start of the data
collection (i.e. 4 weeks after hospitalization for an exacerbation)
- Oral fluency in Dutch
- Being capable to provide informed consent
Exclusion Criteria:
- A documented history of asthma or another respiratory disease
- An expected life expectancy of < 6 months
- Cognitive impairment (Mini Mental State Examination test results < 25) or presence of
other co-morbidities preventing patients from completing the self-report instruments
and/or using electronic monitoring
- Institutionalized patients, patients living in a nursing home or patients not
managing their medications independently