Cognitive Sequelae of Prophylactic Cranial Irradiation in Non-small Cell Lung Cancer Patients
- UICC stage III A or III B (without malignant pleural or pericardial effusion)
non-small cell lung cancer
- Whole body PDG-PET scan before the start of therapy available: no distant metastasis.
- CT or preferably MRI of the brain before the start of radical therapy available; no
- Platinum-based chemotherapy is mandatory.
- Radical local therapy: concurrent or sequential chemotherapy and radiotherapy with or
- Radiotherapy dose without surgery to at least biological equivalent of 60 Gy.
- No prior cranial irradiation.sufficient proficiency in Dutch language
- sufficient proficiency in Dutch language
- MRI (and not CT scan) pre-PCI
Type of Study:
Observational Model: Case-Crossover, Time Perspective: Prospective
The proposed study will investigate the cognitive sequelae of PCI in NSCLC patients in the context of a phase III randomized trial (Nederlandse vereniging van artsen voor longziekten en tuberculose: NVALT-11) on the efficacy of PCI in decreasing the proportion of NSCLC patients developing brain metastasis, and the impact of PCI on neurological symptoms and health-related quality of life.
Outcome Time Frame:
Netherlands: Medical Ethics Review Committee (METC)
- Prophylactic Cranial Irradiation
- lung cancer
- Carcinoma, Non-Small-Cell Lung
- Lung Neoplasms