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Smoking Cessation in Hospitalized Smokers

Phase 4
18 Years
Open (Enrolling)
Smoking Cessation

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Trial Information

Smoking Cessation in Hospitalized Smokers

Most smokers in the U.S. actually do quit smoking when hospitalized, either voluntarily or
involuntarily because of hospital's nonsmoking policy. However, the majority of them return
to smoking soon after their discharge from the hospital. A hospital stay, therefore, is a
"teachable moment" for these patients, a good opportunity to encourage them to lead a
smoke-free life after they are discharged. Research, however, has found that brief
counseling provided to smokers while they are hospitalized has limited effect. The
scientific data clearly show that smokers should be identified at the hospital, provided
counseling, and given intensive interventions with follow up extended to 1 month post
discharge. Providing such clinical services to these patients will reduce their chance of
relapse to smoking and the rate of re-hospitalization. In practice though, hospitals have
had difficulty providing even basic bedside counseling with a subgroup of patients, not to
mention a much longer follow up post-discharge with all patients.

The proposed study aims to demonstrate that state quitlines can help bridge the gap between
the recommendations from existing scientific data and the current practice by hospitals.
Quitlines deliver counseling services by telephone. This is convenient for patients because
they do not have to go anywhere in order to receive the counseling. Moreover, telephone
counseling can be delivered proactively by the counselor.

The potential impact of this study is that if this model is proven effective in a rigorous
study design, then it is likely that state quitlines across the U.S. will adopt it and start
working with hospitals that are interested in using such as system. If the new JCAHO
requirements get adopted, there will be a strong incentive for the hospitals to work with
partners like the quitlines that can help provide follow up counseling.

With the proposed project the investigators intend to establish a practical model that lends
itself to broader dissemination, while testing the effectiveness of the interventions with
the rigor of a randomized design.

Inclusion Criteria:

- 18 years or older

- Smoke >=6 Cigarettes per day

- English or Spanish speaking

- Valid phone number

- Valid address

- Gave consent to participate in study and evaluation

Exclusion Criteria:

- Hospital stay of less than 24 hours

- Inability to communicate orally

- Hypersensitivity to nicotine

- Pregnant

- Hospitalized for psychiatric treatment

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

30-day abstinence

Outcome Description:

All participants will receive an assessment Interview 6-months after their initial contact with the Helpline. The interview will cover, as appropriate, tobacco use, use of quitting aids, pattern of quitting (including slips and relapse situations), and satisfaction with the services. The interview will be conducted over the telephone.

Outcome Time Frame:

6-months post enrollment

Safety Issue:


Principal Investigator

Shu-Hong Zhu, Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:



United States: Institutional Review Board

Study ID:

1U01CA 159533-01



Start Date:

August 2011

Completion Date:

December 2014

Related Keywords:

  • Smoking Cessation
  • tobacco cessation
  • smoking cessation
  • telephone
  • self-help
  • smoking abstinence
  • tobacco use disorder
  • hospital
  • cardiopulmonary diseases
  • disparity
  • Smoking



Scripps Mercy - Chula Vista Chula Vista, California  91910
UCSD - Thornton Hospital La Jolla, California  92037
University of California, San Diego: California Smokers' Helpline San Diego, California  92111
UCSD Medical Center - Hillcrest San Diego, California  92103
Scripps Mercy - San Diego Campus San Diego, California  92103
Univeristy of California, Davis Davis, California  95616