Prevention of Atrial Fibrillation in Patients Undergoing Thoracic Surgery for Lung Cancer
Postoperative atrial fibrillation is one of the most common complication after thoracic
surgery for lung cancer, with an incidence ranging from 8 to 20% after lobectomy and up to
42% after pneumonectomy.
In a recent study we demonstrated that a high perioperative plasma levels of NT-proBNP is
able to identify patients at risk for AF (incidence of 65%).
It has also been demonstrated that the renin-angiotensin system may play an important role
in the pathophysiology of atrial fibrillation and that angiotensin converting enzyme
inhibitors (ACEI) and angiotensin II receptor blockers (ARBs) are able to prevent atrial
fibrillation in patients with heart failure, after myocardial infarction, in hypertensive
patients and after electrical cardioversion.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Incidence of postoperative atrial fibrillation
up to 10 days
Daniela Cardinale, MD
European Institute of Oncology
Italy: The Italian Medicines Agency