Phase III Randomized Trial of Image Guided Intensity Modulated Radiotherapy (IG-IMRT) and Conventional Radiotherapy for Late Toxicity Reduction After Postoperative Radiotherapy in Ca Cervix.
- Histopathological diagnosis of carcinoma cervix with postoperative intermediate or
high risk features.
- Age >18 years.
- Planned for Wertheim's hysterectomy or has already undergone Wertheim's hysterectomy
OR has undergone Simple Hysterectomy with no evidence of residual nodes on MRI/PET
imaging+/- confirmatory nodal biopsy.
- No evidence of paraaortic nodal metastasis.
- History of multiple previous abdominal surgeries placing patient at baseline high
risk of bowel toxicity or any other medical condition with baseline bowel movement
- Rectal Polyps or extensive hemorrhoids.
Type of Study:
Allocation: Randomized, Primary Purpose: Treatment
Late Grade II-IV bowel toxicity
Supriya Chopra, MD,DNB
Department of Radiation Oncology, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre
Data AND Safety Monitoring Committee, Tata Memorial Centre, Mumbai: India
- Cancer Cervix
- IGRT,Postoperative, Cervix, Late toxicity, Bowel