Inclusion Criteria:

- Age range: 18-65 years old

- Histological confirmed diffuse large B-cell lymphoma

- Refractory or first relapsed disease

- Prior anthracycline exposure

- Measurable disease

- ECOG performance status 0-1

- Life expectancy of more than 3 months

- Bone marrow function: ANC≧1.5×109/L, PLT≧100×109/L, Hb≧90g/L

- Liver function: total bilirubin, ALT and AST <1.5×UNL

- Renal function: Cr<1.5×UNL, CCR≧50ml/min

- No contraindication for transplantation

Exclusion Criteria:

- Evidence of CNS and bone marrow involvement

- More than 1 type of chemotherapy regimens exposure

- High level of HBV DNA

- Contraindication of high-dose methylprednisolone

- Pregnant or lactating women

- History of other malignancies except cured basal cell carcinoma of skin and carcinoma
in-situ of uterine cervix

- History of allergic reaction/hypersensitivity to rituximab

- Significant active infection