Trial Information

Predicting Pathological Response Within the 1st Week of Neoadjuvant Chemotherapy Using Functional Parameters Measured With Diffuse Optical Spectroscopic Imaging

Diffuse Optical Spectroscopic Imaging (DOSI) can measure predict markers of response in the
first weeks of therapy.The oxyhemoglobin flare response can predictive of overall
pathological response to chemotherapy in human subjects. These vascular changes can indicate
the rapid transient increase and then decrease in oxyhemoglobin concentration (which is
measurable with DOSI) in the first hours and days after therapeutic administration. The
magnitude and time course of the flare response in patients receiving cytotoxic therapy will
differ between pathological responders and non-responders. This oxyhemoglobin "flare
response" can be observed In tumors where vascular dynamics are intact.