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Italian Study Group on Complicated Diverticulosis: The Natural History of Left-sided Acute Diverticulitis


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Diverticulitis

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Trial Information

Italian Study Group on Complicated Diverticulosis: The Natural History of Left-sided Acute Diverticulitis


Inclusion Criteria:



All consecutive patients with left sided acute diverticulitis diagnosed clinically by the
presence of:

- abdominal pain,

- leukocytosis (>11x109)

- fever >38°C and confirmed by imaging (CT scan, ultrasonography, water soluble
contrast enema)

The CT criteria for the diagnosis included at least one of:

- a localized thickening (≥4 mm) of the colonic wall

- signs of inflammation of the pericolic fat

- abscess

- extraluminal air

- extraluminal contrast

The ultrasound criteria included at least two of:

- bowel wall thickening (>4 mm)

- diverticular inflammation

- pericolic fat edema

- intramural or pericolic inflammatory mass

- intramural fistula

Water soluble contrast enema criteria included at least two of:

- segmental luminal narrowing

- a tethered mucosa

- a mass effect

- extravasation of contrast

- the presence of extraluminal air

Exclusion Criteria:

- inflammatory bowel disease

- irritable bowel syndrome

- colorectal cancer

- diseases precluding adequate follow up

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

to assess the rate of recurrence of acute diverticulitis requiring hospitalization during the follow-up period

Outcome Time Frame:

10 years

Safety Issue:

No

Authority:

Italy: National Monitoring Centre for Clinical Trials - Ministry of Health

Study ID:

GISDIC-1

NCT ID:

NCT01276886

Start Date:

January 1996

Completion Date:

December 1999

Related Keywords:

  • Diverticulitis
  • Left sided acute diverticulitis diagnosed clinically by the presence of abdominal pain, leukocytosis (>11x109) and/or fever >38°C, confirmed by imaging.
  • CT criteria: localized thickening (≥4 mm) of the colonic wall and signs of inflammation of the pericolic fat, abscess and/or extraluminal air and/or contrast.
  • US criteria: bowel wall thickening (>4 mm), diverticular inflammation, pericolic fat edema, intramural or pericolic inflammatory mass, intramural fistula.
  • WSCE criteria: segmental luminal narrowing and a tethered mucosa with or without a mass effect or extravasation of contrast and/or extraluminal air.
  • Diverticulitis
  • Diverticulum

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