Trial Information

Concurrent Endometrial Cancer With Endometrial Hyperplasia or Endometrial Intraepithelial Neoplasia - Focus on Risk Factors Analysis

We retrospectively reviewed the cases of seventy-seven patients who had hysterectomies for
endometrial hyperplasia between January 1996 and September 2006 at the Department of
Obstetrics and Gynecology, National Taiwan University Hospital. A preoperative pathologic
diagnosis of endometrial hyperplasia was obtained by D&C (dilation and curettage) in all
patients. Twenty of them were diagnosed as having endometrial carcinoma in their
hysterectomy specimens. All of the specimens were reviewed by a gynecologic pathologist.

Depending on the final pathologic reports of hysterectomy, we divided the seventy-seven
patients into two groups - the non-endometrial carcinoma group and the endometrial carcinoma
group. Fifty-seven of the studied patients were in the non-endometrial carcinoma group and
twenty were in the endometrial carcinoma group. As already mentioned above, we investigated
them by clinical parameters including age, menopausal status, obstetrical history, medical
history of diabetes and hypertension, BMI (body mass index) and preoperative pathology of
D&C.

The clinical and pathologic characteristics of the twenty patients diagnosed as having
endometrial carcinoma postoperatively were also reviewed. Initial manifestation,
histological grading of the carcinoma, the depth of myometrial invasion, with or without
adjuvant radiotherapy and recurrence were included. The histological grading of endometrial
carcinoma was based on FIGO ( International Federation of Gynecology and Obstetrics )
definitions. The BMIs of the patients with endometrial carcinoma were also analyzed by the
receiver operating characteristic curve. The Research and Ethics Committee of National
Taiwan University Hospital approved this study.

Statistical analyses were performed with the Independent-Samples T test and the Mann-Whitney
test. Subsequently, multivariate analysis of risk factors was also employed with Binary
logistic regression model to obtain the adjusted odds ratio (OR) and 95% confidence interval
(CI) for selective variables. P<0.05 was defined as significant.