Inclusion Criteria:

- ≥ 18 and ≤ 70 years of age

- Histologically or cytologic confirmed advanced non-squamous and non-small cell lung
cancer.

- At least one measurable lesion which has not received radiotherapy (larger than 10 mm
in diameter by spiral CT scan)

- Have failed for 2 lines of chemotherapy including EGFR-TKI.

- ECOG performance scale 0 - 1.

- Life expectancy of more than 3 months.

- Duration from the last therapy is more than 6 weeks for nitroso or mitomycin

- More than 4 weeks after operation or radiotherapy

- More than 4 weeks for cytotoxic agents or tyrosine kinase inhibitors inhibitors

- Adequate hepatic, renal, heart, and hematologic functions (hemoglobin ≥ 90g/L,
platelets ≥ 80×10^9/L, neutrophils ≥ 1.5×10^9/L, total bilirubin within 1.25×the
upper limit of normal(ULN), and serum transaminase≤2.5×the ULN (If liver metastases,
serum transaminase≤5×the ULN), serum creatine ≤ 1.5 x ULN, creatinine clearance rate
≥ 50ml/min,

- signed and dated informed consent.Willingness and ability to comply with scheduled
visits, treatment plans, laboratory tests, and other study procedure.

Exclusion Criteria:

- Squamous cell carcinoma (including adenosquamous carcinoma, undifferentiated
carcinoma); small cell lung cancer (including small cell and non-small cell mixed
lung cancer)

- Pregnant or breastfeeding women

- Intercurrence with one of the following: hypertension, coronary artery disease,
arrhythmia and heart failure

- Any factors that influence the usage of oral administration

- PT, APTT, TT, Fbg abnormal, Receiving the therapy of thrombolysis or anticoagulation.

- Within 4 weeks before the first use of drugs, occurs pulmonary hemorrhage (≥ CTCAE
class 2) or other parts' hemorrhage (≥ CTCAE class 3).

- Long-term untreated wounds or fractures.

- Within 6 months before the first treatment occurs artery / venous thromboembolic
events, such as cerebral vascular accident (including transient ischemic attack),
deep vein thrombosis and pulmonary embolism, etc.

- Application of anticoagulants or vitamin K antagonists such as warfarin, heparin or
its analogues; If the prothrombin time international normalized ratio (INR) ≤ 1.5,
with the purpose of prevention, the use of small doses of warfarin (1mg orally, once
daily) or low-dose aspirin (between 80mg to 100mg daily) is allowed.

- Abuse of alcohol or drugs

- Less than 4 weeks from the last clinical trial

- Treatment with VEGFR, PDGFR, sSRC-TKI before.

- History of any second malignancies within 3 years except cured basal cell carcinoma
of skin and carcinoma in-situ of uterine cervix.