Inclusion Criteria:

1. Grade >= 2 cutaneous and/or subcutaneous fibrosis (NCI-CTCAE v4 toxicities scale)
revealed from 6 to 24 months after head and neck radiotherapy.

2. Head and neck cancers treated by radiation therapy +/- chemotherapy, +/- surgery,
with no evidence of progressive disease.

3. Age >= 18

4. Karnofsky PS ≥ 70

5. normal renal function (plasmatic creatinine <= 130 micromol/l), normal cholesterol,
normal hepatic function (total bilirubin <= 1.5 UNL, SGOT and SGPT <= 2 UNL)

6. Written informed consent of the patient.

Exclusion Criteria:

1. any chronic treatment by corticoids

2. severe cardiac pathology

3. patients already treated by statins or treated by fibrates, cyclosporine

4. history of muscular toxicities when treated by fibrates or by statins

5. Personal or familial history of hereditary muscular pathology

6. Plasmatic CPK >3 UNL

7. patient already included in another therapeutic trial with an experimental drug,

8. pregnant patient or susceptible to pregnancy or breast feeding (patients in age to
give birth must be placed under efficient contraception),

9. a social or psychological condition that does not allow a positive patient's
participation in the treatment and necessary medical follow-up to be envisaged,

10. the patient is under legal restrained or tutelage.