Inclusion Criteria

Inclusion criteria:

- Cyto-/histological confirmed unresectable, locally advanced, or metastatic biliary
tract cancer, including intrahepatic or extrahepatic cholangiocarcinoma or
adenocarcinoma of gallbladder, but NOT other peri-ampulla Vateri or mixed tumor.

- At least one, not previously irradiated, measurable lesion according to RECIST
(version 1.1).

- Eastern Cooperative Oncology Group (ECOG) performance score of 0-1.

- Aged no less than 20 years, at the time of acquisition of informed consent.

- Life expectancy >= 3 months.

- Adequate organ and bone marrow function as defined below: WBC >= 3.00 × 103/L and
absolute neutrophil count >= 1.50 × 103/L, Platelet count >= 100 × 103/L, Hemoglobin
level >= 10 g/dL, Serum creatinine <= 1.5 x Upper Normal Limit (UNL) and calculated
GFR >= 40mL/min, Serum bilirubin <= 1.5 x UNL , ALT <= 2.5x UNL.

- Ability to understand and willingness to sign written Informed Consent Form.

Exclusion criteria:

- Other anti-tumor agent such as systemic chemotherapy, immunotherapy or
EGFR/VEGF-pathway-targeting therapy before the commencement of study treatment.

- Radiotherapy (except palliative irradiation of bone lesions) within 4 weeks before
the commencement of study treatment.

- Other cancer or prior treatment for other carcinomas within the last five years,
except cured non-melanoma skin cancer and treated in-situ cervical cancer.

- Known CNS metastasis.

- Major surgery within 4 weeks prior to start of study treatment (diagnostic biopsy,
laparotomy, line placement is not considered as major surgery).

- Pre-existing peripheral neuropathy >= grade 2.

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, myocardial infarction in the past 12
months, active gastrointestinal bleeding, central nervous system disorders or
psychiatric illness/social situation that would limit compliance with study
requirements or judged to be ineligible for the study by the investigator.

- Having received any investigational agents or participated in any investigational
drug study within 4 weeks prior to study enrollment.

- Pregnant or breast-feeding female (a pregnancy test must be performed on all female
patients who are of child-bearing potential before entering the study, and the result
must be negative).

- Poor compliance.