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The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery


N/A
18 Years
N/A
Open (Enrolling)
Both
Lung Neoplasms, Esophageal Neoplasms, Venous Thromboembolism

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Trial Information

The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery


Inclusion Criteria:



- clinical diagnosis of esophageal carcinoma and planned for esophagectomy

- clinical diagnosis of lung carcinoma and planned for lung resection

- general anesthesia combined with epidural anesthesia

Exclusion Criteria:

- blood clotting disfunction before surgery

- anticoagulating or antiplatelet history before surgery

- low blood platelets count

- hemorrhagic disease

- cerebral hemorrhage

- cerebral,spinal,ophthalmologic operation history

- peptic ulcer

- bleeding>400ml in operation

- bleeding>100ml/h after operation

- blood transfusion in or after operation

- severe renal or liver disfunction

- severe hypertension

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Outcome Measure:

TEG values

Outcome Description:

1.5ml aterial blood sample will be obtained daily for TEG , and the vulues of TEG,such as R,K,Alpha angle,MA,G,CI ,will be measured

Outcome Time Frame:

three days after surgery

Safety Issue:

Yes

Principal Investigator

Lizhen Xuan

Investigator Role:

Principal Investigator

Investigator Affiliation:

Shanghai Zhongshan Hospital

Authority:

China: Ministry of Health

Study ID:

SICUTEG-01

NCT ID:

NCT01267305

Start Date:

July 2011

Completion Date:

April 2013

Related Keywords:

  • Lung Neoplasms
  • Esophageal Neoplasms
  • Venous Thromboembolism
  • esophagectomy
  • lung resection
  • venous thromboembolism
  • low molecular weight heparin
  • chest drainage
  • TEG
  • Neoplasms
  • Esophageal Diseases
  • Esophageal Neoplasms
  • Hemorrhage
  • Lung Neoplasms
  • Thromboembolism
  • Venous Thromboembolism
  • Venous Thrombosis

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