Trial Information
The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery
Inclusion Criteria:
- clinical diagnosis of esophageal carcinoma and planned for esophagectomy
- clinical diagnosis of lung carcinoma and planned for lung resection
- general anesthesia combined with epidural anesthesia
Exclusion Criteria:
- blood clotting disfunction before surgery
- anticoagulating or antiplatelet history before surgery
- low blood platelets count
- hemorrhagic disease
- cerebral hemorrhage
- cerebral,spinal,ophthalmologic operation history
- peptic ulcer
- bleeding>400ml in operation
- bleeding>100ml/h after operation
- blood transfusion in or after operation
- severe renal or liver disfunction
- severe hypertension
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Outcome Measure:
TEG values
Outcome Description:
1.5ml aterial blood sample will be obtained daily for TEG , and the vulues of TEG,such as R,K,Alpha angle,MA,G,CI ,will be measured
Outcome Time Frame:
three days after surgery
Safety Issue:
Yes
Principal Investigator
Lizhen Xuan
Investigator Role:
Principal Investigator
Investigator Affiliation:
Shanghai Zhongshan Hospital
Authority:
China: Ministry of Health
Study ID:
SICUTEG-01
NCT ID:
NCT01267305
Start Date:
July 2011
Completion Date:
April 2013
Related Keywords:
- Lung Neoplasms
- Esophageal Neoplasms
- Venous Thromboembolism
- esophagectomy
- lung resection
- venous thromboembolism
- low molecular weight heparin
- chest drainage
- TEG
- Neoplasms
- Esophageal Diseases
- Esophageal Neoplasms
- Hemorrhage
- Lung Neoplasms
- Thromboembolism
- Venous Thromboembolism
- Venous Thrombosis