Image Guided Adaptive Multi-modality Therapy in the Treatment of Gliomas
I. To correlate the imaging findings with pathological grade following surgery in patients
with newly diagnosed intra-cranial gliomas.
I. To determine the feasibility of defining the optimal target volume for radiation therapy
using MR spectroscopy, diffusion, perfusion and functional imaging. II. To monitor
therapeutic responses following treatment using MR spectroscopy, diffusion imaging and
III. To monitor changes in neurocognitive functioning following image guided therapy.
OUTLINE: Patients undergo magnetic resonance spectroscopic imaging, functional magnetic
resonance imaging (MRI), diffusion-weighted MRI, and perfusion-weighted MRI. Patients then
undergo maximum surgical resection followed by intensity-modulated radiation therapy (IMRT)
5 days a week for 6 weeks. After completion of study treatment, patients are followed up
every 3 months for the first year then every 6 months for another year.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Feasibility of identifying low grade and high grade tumor location with imaging techniques that include MRSI,perfusion MRI, and DTI
Twice a year, after enrollment of first 25 patients, and at study completion
Joshua Silverman, MD
New York University School of Medicine
United States: Institutional Review Board
|NYU Cancer Institute||New York, New York 10016|