Inclusion Criteria

Inclusion Criteria

1. Patient with chronic HBV DNA and/or with symptoms of liver cirrhosis

2. Patient with Hepatocellular carcinoma evidenced by sonography, CT scan, or MRI scan)

3. Patient is 18 years and older.

4. Patient is documented to be HBsAg positive for > 6 months.

- Laboratory report proving HBsAg positive or HBeAg positive for at least six
months

- IgM anti-HBc negative, IgG anti-HBc positive at screening

5. Patient is HBV DNA positive with DNA levels ≥ 2,000 IU/mL within 30 days of baseline.

6. Patient has ALT or AST levels >=40 IU/L

7. Cell carcinoma/hepatocellular carcinoma patient who is anticipated to live at least 1
year.

8. Patient who is fully active, able to carry on all pre-disease performance without
restriction or restricted in physically strenuous activity but ambulatory and able to
carry out work of a light or sedentary nature, e.g., light house work, office work.

9. Patient who is classified as NYHA functional classification grade 1-2. (NYHA;New York
Heart Association)

10. Patient who is able to give written informed consent prior to study start and to
comply with the study requirements.

Exclusion Criteria

1. Patient is currently receiving antiviral therapy.

2. Patients previously treated with interferon, peg-interferon or other immunomodulatory
within the previous 6 months.

3. Patients previously treated with clevudine, lamivudine, adefovir, entecavir,
telbivudine, tenofovir or any other investigational nucleoside for HBV infection.

4. Patient is coinfected with HCV, HDV or HIV.

5. Patient with metastatic malignancy.

6. Patient with previous liver transplantation

7. Patient is pregnant or breast-feeding.

8. Patient has a clinically relevant history of abuse of alcohol or drugs.

9. Patient use oriental medicine within the previous 2 weeks.

10. Patient has a significant immunocompromised, gastrointestinal, renal, hematological,
psychiatric, bronchopulmonary, biliary diseases excluding asymptomatic GB stone,
neurological, cardiac, oncologic(except HCC)or allergic disease or medical illness
that in the investigator's opinion might interfere with therapy.

11. Patient has creatinine clearance less than 60mL/min as estimated by the following
formula: (140-age in years) (body weight [kg])/(72) (serum creatinine [mg/dL]) [Note:
multiply estimates by 0.85 for women]