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The Relationship Between Epicardial Adipose Tissue Thickness, Insulin Resistance and Plasma Adiponectin Concentrations In Patients With Polycystic Ovary Syndrome


Phase 4
18 Years
44 Years
Not Enrolling
Female
Epicardial Adipose Tissue Pcos

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Trial Information

The Relationship Between Epicardial Adipose Tissue Thickness, Insulin Resistance and Plasma Adiponectin Concentrations In Patients With Polycystic Ovary Syndrome


Context: Polycystic ovary syndrome (PCOS) is characterized with chronic oligo/unovulations,
hyperandrogenism and insulin resistance. Insulin resistance is mostly attributed to visceral
adipose tissue. Epicardial adipose tissue thickness (EATT) is in close relation with
atherosclerotic coronary heart disease and its importance in PCOS is not determined yet.
Thus, we aimed to clarify EATT in patients with PCOS and compare with healthy matched
controls. In addition we searched plasma adiponectin levels to clarify its relationship with
EATT in patients with PCOS.

Settings: EATT was determined by echocardiography. Insulin resistance is calculated as
HOMA-IR and plasma adiponectin levels were determined with ELISA radioimmunoassay at G├╝lhane
School of Medicine, Ankara, Turkey.

Patients: Patients with PCOS and healthy controls who were similar in body mass index (BMI)
and age (p=0.118, p=0.081, respectively) were enrolled in the study after having their
written consents.

Results: Mean EATT and HOMA-IR levels were significantly higher (p=0.001, p=0.001,
respectively) while plasma adiponectin concentrations were significantly lower (p=0.0032) in
patients with PCOS than controls. There was no correlation between plasma adiponectin levels
and EATT in subjects (p=0.824). EATT levels were in positive correlation with HOMA-IR,
plasma triglyceride concentrations and body mass index (BMI) (p=0.022, p=0.027, p=0.022,
respectively). HOMA-IR, triglyceride levels, HDL-Cholesterol, LH/FSH ratio were most
powerful determinants of EATT in logistic regression modeling (p=0.016, p=0.021, p=0.049,
p=0.039, respectively).

Conclusion: EATT is increased in patients with PCOS in concordance with HOMA-IR level and
these findings may reflect the increased risk for atherosclerotic cardiovascular disease in
this particular patient group.


Inclusion Criteria:



- pcos patients, all of the women had normal thyroid-stimulating hormone and prolactin
levels, and subjects without possible ovarian tumors, congenital adrenal hyperplasia

Exclusion Criteria:

- BMI greater than 35 kg/m2, any chronic renal or liver disease

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Mean EATT and HOMA-IR levels were significantly higher (p=0.001, p=0.001, respectively) while plasma adiponectin concentrations were significantly lower (p=0.0032) in patients with PCOS than controls.

Outcome Description:

june 2009-june 2010

Outcome Time Frame:

1 year

Safety Issue:

Yes

Authority:

Turkey: Ministry of Health

Study ID:

1491-764-10/1539

NCT ID:

NCT01258946

Start Date:

January 2009

Completion Date:

August 2010

Related Keywords:

  • Epicardial Adipose Tissue Pcos
  • epicardial adipose pcos
  • Polycystic Ovary Syndrome

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