Effects of Preoperative Immunonutrition on Infectious Complication and Th1/Th2 Differentiation in Patients Undergoing Pancreaticoduodenectomy
18 Years
N/A
Both
Pancreatic Cancer, Bile Duct Cancer
Trial Information
Effects of Preoperative Immunonutrition on Infectious Complication and Th1/Th2 Differentiation in Patients Undergoing Pancreaticoduodenectomy
The investigators reported that preoperative immunonutrition improve the incidence of
postoperative infectious complication in patients after pancreaticoduodenectomy, and
modulation of Th1/Th2 differentiation may play important roles in this effect.
Object of this study is to investigate the effects preoperative immunonutrition on incidence
of postoperative infectious complication, and Th1/Th2 balance after pancreaticoduodenectomy.
Inclusion Criteria:
- patients underwent pancreaticoduodenectomy
Exclusion Criteria:
- age younger than 18 years
- ongoing infection
- gastrointestinal obstruction
- respiratory dysfunction
- cardiac dysfunction
- hepatic dysfunction
- renal failure
- history of recent immunosuppressive or immunological diseases
- preoperative evidence of widespread metastatic disease
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Outcome Measure:
Postoperative Infectious Complication
Outcome Time Frame:
30 days
Safety Issue:
No
Principal Investigator
Katsunori Furukawa, MD
Investigator Role:
Study Director
Investigator Affiliation:
Chiba University
Authority:
Japan: Institutional Review Board
Study ID:
furukawa2009
NCT ID:
NCT01256034
Start Date:
May 2009
Completion Date:
March 2012
Related Keywords:
- Pancreatic Cancer
- Bile Duct Cancer
- immunonutrition
- pancreaticoduodenectomy
- Th1
- Th2
- Pancreatic Neoplasms
- Bile Duct Neoplasms
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