18F-Fluoride PET Bone Scans Versus Traditional 99mTc-MDP Gamma Camera Bone Scans for the Diagnosis of Bone Metastases: a Blinded, Prospective Trial
Compare the diagnostic sensitivity, specificity, and accuracy of 18F-Fluoride PET bone scans
versus traditional 99mTc-MDP bone scans for detecting bone metastases.
Determine if there is a significant change in clinical management between the two types of
Measure and compare the number of equivocal or uncertain findings that would have caused
additional testing, particularly additional imaging studies, to be performed for
confirmation when using 18F-Fluoride PET bone scans versus 99mTc-MDP bone scans.
To quantify any adverse events resulting from either scan.
To perform subgroup analyses according to cancer cell type.
Observational Model: Cohort, Time Perspective: Prospective
Accurate identification of bone metastases
Individual subjects will be reviewed 6-12 months after their bone scans, utilizing all clinical and imaging data available, to determine diagnostic accuracy of each bone scan.
Upon study completion (2-3 years)
David Djang, MD
Seattle Nuclear Medicine
United States: Institutional Review Board
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