Inclusion Criteria:

- Previously untreated acute lymphoblastic leukaemia (pro-B, common, pre-B, early T,
thymic T, mature T)

- Age 18 years - 55 years

- Treatment according to German Multicenter Trials for adult Acute Lymphoblastic
Leukaemia (GMALL) 07/2003 protocol or subsequent GMALL protocols for patients with de
novo ALL

- Written informed consent

- Women of child-bearing potential or partner of men with child-bearing potential must
use a highly effective method of contraception

- Negative pregnancy test for women of child-bearing potential

Exclusion Criteria:

- Patients with Philadelphia chromosome (BCR-ABL) positive ALL

- Severe comorbidity or leukaemia-associated complications

- Known hypersensitivity to asparaginase

- History of severe pancreatitis

- History of thrombosis or pulmonary embolism

- Pre-existing clinically relevant coagulopathy

- Liver dysfunction (e.g. acute or current hepatitis, alcohol or drug abuse) or history
of clinically relevant liver disease

- Bilirubin > 1.5 x Upper Limit Norm (ULN)

- Other current malignancies

- Severe psychiatric illness or other circumstances which may compromise the
cooperation of the patient or the ability to give informed consent

- Body mass index > 30 kg/m²

- Known pregnancy, breast feeding