Three Dimension Neuron Imaging Using 123I-metaiodobenzylguanidine Single Photon Emission Computed Tomography to Guide Ventricular Tachycardia Ablations
Ventricular tachycardia is the next frontier in cardiology. Patients that have scar in the
heart (for example after heart attacks) are at an increased risk of developing ventricular
tachycardia. In these patients ventricular tachycardia represents an electrical wave front
that circulates in the heart muscle using the scar in the heart. An increasing number of
patients with ventricular tachycardia require cauterization (burning away) of the tissue to
treat this life-threatening condition. The goal of this cauterization or ablation is to
destroy "highways of surviving tissue" inside the scar, that allow ventricular tachycardia
to exist. However, this can be very lengthy procedure (>5 hours) that has only a moderate
success in the long run. Therefore, new treatment approaches are needed to make this
procedure better.
The purpose of this study is to assess if radio tracers showing the nerve distribution in
the heart (cardiac innervation) can be used in addition to the current technology ("voltage
mapping") to identify the area that needs to be ablated (burnt away) to treat
life-threatening fast heart rates (ventricular tachycardia)
Certain patterns of nerve distribution in the heart (sympathetic cardiac innervation) have
been shown to predict outcome for different heart diseases, like heart transplant, coronary
artery disease, heart failure, arrhythmias. One substance that allows visualization of the
cardiac innervation is 123I-metaiodobenzylguanidine (123I-MIBG), which could provide
additional information to understand and treat ventricular tachycardia.
Interventional
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Imaging of Nerve distribution in heart
Specific Aim 1: Evaluate if areas of left ventrical (LV) denervation measured by cardiac 123I-metaiodobenzylguanidine (MIBG) SPECT imaging (innervation map) can be integrated into the CartoXP electrophysiology mapping system. Participants will be followed for 6 months for an episode of Ventricular Tachycardia.
6 months after procedure
No
Timm R Dickfeld, MD,Ph.D
Principal Investigator
University of Maryland
United States: Institutional Review Board
HP-00043324
NCT01250912
March 2010
December 2012
Name | Location |
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University of Maryland Medical Center, EP Lab, Rm. N3W77 | Baltimore, Maryland 21201 |