The Influence of Sunitinib on Contractility of Human Atrial Trabeculae
18 Years
N/A
Both
Cardiotoxicity, Ischemia, Heart Failure
Trial Information
The Influence of Sunitinib on Contractility of Human Atrial Trabeculae
Study population: 44 (+22) patients undergoing CABG cardiac surgery with extracorporal
circulation Intervention (if applicable): none (pharmacological interventions will only be
performed ex-vivo in isolated atrial tissue) Main study parameters/endpoints The developed
force in ex vivo atrial trabeculas during standardized stimulation.
Inclusion Criteria:
- Cardiac surgery with extracorporal circulation
Exclusion Criteria:
- Use of oral antiarrhythmics
- theophylline use
- Use of sulfonylureas
- Atrial arrythmias
- Right ventricular failure
Type of Study:
Observational
Study Design:
Observational Model: Case-Only
Outcome Measure:
Force
Outcome Description:
The developed force in ex vivo atrial trabeculae during standardized stimulation.
Outcome Time Frame:
200 minutes
Safety Issue:
No
Principal Investigator
G. A. Rongen
Investigator Role:
Principal Investigator
Investigator Affiliation:
Radboud University
Authority:
Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
Study ID:
SCAR
NCT ID:
NCT01246778
Start Date:
November 2010
Completion Date:
November 2013
Related Keywords:
- Cardiotoxicity
- Ischemia
- Heart Failure
- Heart Failure
- Ischemia
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