Inclusion Criteria:

- Received between 1 to 4 prior lines of therapy

- Measureable disease

- Men and women of childbearing potential (WOCBP) must be using two acceptable methods
of contraception

- Men must agree to use a latex condom and a second form of birth control during sexual
contact with WOCBP and must agree to not donate semen during study drug therapy

- Subjects must be willing to refrain from blood donations during study drug therapy

Exclusion Criteria:

- Subjects with non-secretory or oligo-secretory or light-chain only myeloma or
active/prior plasma cell leukemia or known /suspect POEMS syndrome

- Solitary bone or solitary extramedullary plasmacytoma as the only evidence of plasma
cell dyscrasia

- Unable to take aspirin daily as prophylactic anticoagulation therapy. Prior history
of inability to tolerate weekly 40 mg dexamethasone

- History of renal failure

- History of clinical significant thrombosis, such as treatment for thrombosis was
required