Vitamin D, Weight Loss, and Breast Cancer Biomarkers
50 Years
75 Years
Female
Breast Cancer, Obesity, Hypovitaminosis D
Trial Information
Vitamin D, Weight Loss, and Breast Cancer Biomarkers
Objective: To test the incremental effect of vitamin D supplementation (2000 IU/day) in 228
overweight and obese postmenopausal women with low blood vitamin D levels on response to a
weight loss (diet + exercise) intervention in a double-blind placebo-controlled clinical
trial.
Primary Aim:
• Determine the effects of 12-months vitamin D supplementation vs. placebo on weight loss in
women following a weight loss diet and exercise program.
Secondary Aims:
- Determine the effects of 12-months vitamin D vs. placebo on blood biomarkers associated
with increased breast cancer risk (insulin, glucose, CRP).
- Test 12-months vitamin D effects on muscle strength as measured by 1RM leg press and
bench press in women undergoing weight loss.
- Test the effect of 12-month vitamin D supplementation on effects on quality of life
(QOL) in women undergoing weight loss.
Additional Aims:
- In a 50% subset of women, test the effect of 12-month vitamin D supplementation vs.
placebo on breast epithelial cell cytomorphology (quantified by the Masood cytology
index) obtained through random periareolar fine needle aspiration (RPFNA).
- Collect subcutaneous abdominal fat aspirations in the 50% subsample of women.
OUTLINE: This is a randomized study. Participants are stratified according to body mass
index (< 30 vs ≥ 30) and RPFNA-consent. All participants will receive a 6-month weight loss
intervention (prescribed weight loss goal of 10% of initial body weight) followed by 6
months' maintenance therapy.
Baseline, 6-, and 12-month measurements will include weight, BMI, waist and hip
circumference, serum 25-hydroxyvitamin D, fasting blood samples, and questionnaires on
details of diet especially items containing vitamin D, physical activity levels, sun
exposure including clothing and sunscreen habits, dietary supplement and vitamin use, and
medications.
Inclusion Criteria:
- Age 50-75 years
- Postmenopausal (no periods for past 12 months)
- Screening serum vitamin D (25(OH)D) between 10 and 32 ng/mL ("insufficient")
- No menopausal HRT use of any type including vaginal X 6 months and willing to avoid
use for study duration
- BMI > 25.0 kg/m2 (> 23.0 for Asians)
- Physically able to undertake a calorie reduction and exercise program
- Able to come for clinic visits, classes, and measurements, fill out questionnaires
and logs in English
- Gives informed consent, agrees to be randomly assigned
Exclusion Criteria:
- Currently using more that 400 IU vitamin D from supplemental sources
- Screening vitamin D level < 10 ng/mL (will be referred to primary provider) or > 32
ng/mL (already sufficient)
- Osteoporosis
- Renal disease, history of kidney stones
- Any contra-indications to taking vitamin D 2000 IU/day
- Plans to leave the study area within the follow-up period
- Plans to join another organized weight loss program or take appetite suppressant
medication during the study period
- History of bariatric surgery
- Current use of medications likely to interfere with adherence to interventions or
study outcomes
- Current smoker
- Personal history of invasive or in situ breast cancer
- Personal history of invasive cancer other than breast: except for non- melanoma skin
cancer which would be eligible
- Diabetes mellitus
- Abnormalities on screening physical that contraindicate participation
- Severe congestive heart failure per NYHA criteria 3 & 4
- Contraindications for entry into a research exercise program: recent (within 6
months) myocardial infarction, pulmonary edema, myocarditis, pericarditis, unstable
angina, pulmonary embolism, deep vein thrombosis, uncontrolled hypertension (systolic
> 200, diastolic > 100), orthostatic hypotension, moderate/severe aortic stenosis,
uncontrolled arrythmia, uncontrolled congestive heart failure, left bundle branch
block, history of cardiac arrest or stroke
- Alcohol or drug abuse, significant mental illness (as assessed by study staff
impression)
- For the RPFNA/adipose tissue substudy: bilateral breast cancer, bilateral mastectomy,
unable or unwilling to stop aspirin or NSAIDs for 1 week before and after the
procedure, allergy to anesthetics or local anesthetics.
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)
Outcome Measure:
Compare the effects of a 1-year one year Vitamin D supplementation vs placebo, on weight loss in postmenopausal women following a weight loss diet and exercise program.
Outcome Time Frame:
One Year
Safety Issue:
No
Principal Investigator
Anne McTiernan, MD, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Fred Hutchinson Cancer Research Center
Authority:
United States: Institutional Review Board
Study ID:
SAC110024
NCT ID:
NCT01240213
Start Date:
October 2010
Completion Date:
September 2012
Related Keywords:
- Breast Cancer
- Obesity
- Hypovitaminosis D
- Vitamin D
- lifestyle intervention
- postmenopausal women
- Breast Neoplasms
- Obesity
- Rickets
- Avitaminosis
Name | Location |
|---|---|
| Fred Hutchinson Cancer Research Center | Seattle, Washington 98109 |
