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Assessment of Stem Cell Heterogeneity in AML in Co-Culture Systems Using X Chromosome Inactivation Patterns


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Open (Enrolling)
Female
Leukemia

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Trial Information

Assessment of Stem Cell Heterogeneity in AML in Co-Culture Systems Using X Chromosome Inactivation Patterns


OBJECTIVES:

- Determine the frequency of acute myeloid leukemia (AML) that originates in CD33+
precursors or in which uncontrolled growth is restricted to CD33+ precursors.

OUTLINE: Cryopreserved acute myeloid leukemia cell samples are separated from endothelial
cell by fluorescent-activated cell sorting (FACS) and analyzed for X-chromosome inactivation
patterns by cytogenetic/molecular analysis and/or Humara assay.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosed with acute myeloid leukemia

- Known CD34+ progenitor cells

- Available freshly isolated, uncultured cell samples

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Frequency of AML that originate in CD33+ or in which uncontrolled growth is restricted to CD33+ precursors

Safety Issue:

No

Principal Investigator

Roland Walter, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Fred Hutchinson Cancer Research Center

Authority:

United States: Federal Government

Study ID:

CDR0000687880

NCT ID:

NCT01232842

Start Date:

October 2010

Completion Date:

Related Keywords:

  • Leukemia
  • adult acute myeloid leukemia
  • childhood acute myeloid leukemia/other myeloid malignancies
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

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