Inclusion Criteria:

1. Diagnose: therapy-naïve ALL, except for patients that performed Induction for ALL (33
days) exactly as this protocol and; documented Ph+, to be confirmed by conventional
cytogenetic - t(9;22) (q34;q11) or FISH and/or gene BCR-ABL presence by RT-PCR or
FISH.

2. Female patients of childbearing age, should have pregnancy test (blood βhCG)
performed before treatment initiation. Effective contraception must be used during
treatment. Pregnant women won't be included.

3. Life expectation > 8 weeks.

4. Medications: antineoplastic treatment-naïve, including corticotherapy, except for
patients that performed Induction for ALL (33 days) exactly as this protocol.

5. Signed ICF by child legal responsible.

6. Laboratory: renal function (serum creatinine ≤ 1,5 x ULN and/or Clearance ≥70
ml/min/1,73m2), hepatic function (total bilirubin ≤ 1,5 x ULN, TGP/TGO < 10 x ULN and
albumin > 2 g/dl.

Exclusion Criteria:

1. Any inclusion criteria missing.

2. Pregnant patient or breastfeeding.

3. Patient considered incapable to follow purposed treatment.

4. Subject with infectious process, in activity, grade IV.