Inclusion Criteria:

- T2-T3 operable infiltrating breast carcinoma

- No allergy to Patent Blue

- Pre-operative diagnosis of unilateral infiltrating breast carcinoma.

- Patient planned to be treated by NAC.

- Informed consent.

- Surgery available 4 to 6 weeks after the last chemotherapy course (radical or
conservative surgery)

Exclusion Criteria:

- pT4d (inflammatory breast cancer)

- Locally advanced or metastatic breast cancer

- Any previous chemotherapy of contra-lateral breast cancer.

- Breast cancer local relapse

- Previous surgical removal of breast Cancer.

- Inadequate biopsy for pathological analysis.

- Dementia or altered mental disorder

- Pregnant woman or breast feeding or without efficacious contraceptive method.

- Contra-indication to NAC NAC interrupted due to progressive disease.