Inclusion Criteria:

Dose escalation period for both schedules:

- Patient must have a confirmed diagnosis of acute leukemia regardless of sub-type for
whom experimental phase 1 therapy is appropriate

- Are greater than or equal to 18 years of age

- Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
scale

- Females with childbearing potential must have had a negative urine or serum pregnancy
test less than or equal to 7 days prior to the first dose of study drug

Dose confirmation period for both schedules:

- Participant must have a confirmed diagnosis of untreated AML, should not be a
candidate for standard therapy, and a clinical trial is a preferred treatment option
or acute AML that is relapsed or refractory to no more than 2 prior induction
regimens. Hydroxyurea to control prior blast counts is not considered a prior
regimen.

- Are greater than or equal to 60 years of age

- Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
scale

- Females with childbearing potential must have had a negative urine or serum pregnancy
test less than or equal to 7 days prior to the first dose of study drug

Exclusion Criteria:

- Have received treatment within 28 days of the initial dose of study drug with a drug
that has not received regulatory approval for any indication.

- Participants with known central nervous system (CNS) leukemia by spinal fluid
cytology or imaging. A lumbar puncture is not required unless CNS involvement is
clinically suspected. Participants with signs or symptoms of leukemic meningitis or a
history of leukemic meningitis must have a negative lumbar puncture within 2 weeks of
study enrollment.

- Have other active malignancy (with the exception of basal and squamous cell skin
cancer) at time of study entry

- Have had an autologous or allogenic bone marrow transplant within 3 months. All organ
toxicity must be resolved.

- Have evidence of graft-versus-host disease due to an allogenic bone marrow transplant

- Have uncontrolled systemic infection

- Females who are pregnant or lactating

- Have known positive test results in human immunodeficiency virus (HIV), hepatitis B
surface antigen (HBSAg), or hepatitis C antibodies (HCAb) (screening not required)