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Evaluation of Respiratory Motion-Corrected Cone-Beam CT in Radiation Treatment of Thoracic and Abdominal Cancers

18 Years
Open (Enrolling)
Gastric Cancer, Lung Cancer

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Trial Information

Evaluation of Respiratory Motion-Corrected Cone-Beam CT in Radiation Treatment of Thoracic and Abdominal Cancers

Inclusion Criteria:

- Patients must have histologic proof of a thoracic or abdominal malignancy, confirmed
at MSKCC and suitable for radiation therapy, in order to be eligible for this study.
Thoracic malignancies (study group 1) include those in lung and gastro-esophageal
junction. Abdominal malignancies (study group 2) include those in liver and pancreas.
Patients having both thoracic and abdominal malignancies will be placed in only one
of the study groups, because the limited field-of-view of the CBCT precludes imaging
of both malignancies in the same scan. Patients must be older than 18 years of age

- At least part of the tumor must be visible as observed in a diagnostic or planning
CT. The tumor must exhibit at least 5 mm motion from respiration as observed in the
respiration-correlated CT (RCCT) at simulation. The RCCT scan must be interpretable
and not exhibit excessive motion artifacts caused by irregular patient breathing.

- Patients must have Karnofsky Performance Status ≥ 70%

Exclusion Criteria:

- Mesothelioma and other tumors of the pleura

- Pregnant Women

- Allergic to iodine or intravenous contrast agent (applies only to patients with a
pancreas or liver malignancy)

- Renal impairment due to the use of a contrast agent

- Patients with pacemakers and defibrillators

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

To determine whether motion-corrected cone-beam CT (CBCT) improves the localization accuracy

Outcome Description:

of thoracic tumors (evaluated using study group 1) and organs-at-risk (evaluated using study group 2) relative to the standard cone-beam CT procedure.

Outcome Time Frame:

2 years

Safety Issue:


Principal Investigator

Gikas Mageras, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

September 2010

Completion Date:

September 2014

Related Keywords:

  • Gastric Cancer
  • Lung Cancer
  • gastro-esophageal junction
  • lung
  • abdominal
  • cone-beam CT (CBCT)
  • 10-146
  • Lung Neoplasms
  • Stomach Neoplasms
  • Abdominal Neoplasms



Memorial Sloan-Kettering Cancer Center New York, New York  10021