Inclusion Criteria:

- Histologically confirmed diagnosis of recurrent PVNS ( or diffuse-type giant cell
tumor or tenosynovial giant cell tumor) that is unresectable, metastatic, or for
which the patient refuses surgical intervention

- Progressive disease in the last 12 months, as demonstrated by imaging or clinical
appearance of new tumors, in the opinion of the treating investigator

- At least one site of measurable disease according to RECIST 1.1 on MRI (or CT scan
for metastatic disease)

- Any number or type of prior systemic therapies, with the exception of known or
suspected CSF1 receptor inhibitors as outlined in exclusion criteria below

- 18 years of age or older

- Life expectancy greater than 6 months

- ECOG Performance Status of 0, 1 or 2

- Normal organ and marrow function as defined in the protocol

- QTc less than or equal to 450 ms on 12-lead ECG

- Negative urine or serum pregnancy test within days of start of study drug
administration for women of childbearing potential.

- Women of childbearing potential and men must agree to use adequate contraception
prior to study entry, for the duration of study participation, and for 3 months
following study drug discontinuation

Exclusion Criteria:

- Prior treatment with known or suspected CSF1 receptor inhibitor, including nilotinib,
imatinib, sunitinib, or sorafenib, or other approved or investigational tyrosine
kinase inhibitors used for treatment of diffuse-type giant cell tumor

- Concurrent treatment with other investigational agents

- Inability to tolerate or contraindication to MRI scanning for participants with
localized disease

- Impaired cardiac function

- Current treatment with strong CYP3A4 inhibitors that cannot either be discontinued or
switched to a different medication prior to starting study drug

- Current treatment with any medications that have the potential to prolong the QT
interval and that cannot either be discontinued or switched to a different medication
prior to starting study drug

- Impaired gastrointestinal (GI) function or GI disease that may significantly alter
the absorption of study drug

- Acute or chronic pancreatic disease

- Acute or chronic liver disease

- Another primary malignant disease requiring systemic treatment or radiation

- History of significant congenital or acquired bleeding disorder unrelated to cancer

- Major surgery within 28 days prior to Day 1 of the study

- Treatment with other investigational agents within 28 days of day 1

- History of non-compliance to medical regimens or inability to grant consent

- Women who are pregnant or breastfeeding

- Other comorbidities that would interfere with study participation or safety in the
opinion of the investigator