Trial Information

Effect of Bone Marrow-derived Mesenchymal Stem Cell Transplantation in Reconstructing Bone Defects.

Bone cysts are benign lesions usually discovered in children from age of 5 to 15 years.
Treatment options include observation, corticosteroid injection and surgery. Sometimes the
risk of surgery is comparable to the likelihood of fracture without treatment. In orthopedic
surgery, bone chips , various types of ceramics, natural and synthetized bone mineral
hydroxyapatite and tricalcium phosphate, as well as numerous polymers and co-polymers of
alfa-hydroxy acids are used to perform as an osteoconductive and rarely osteoinductive
factor to help bone formation.Some evidence demonstrated that bone marrow mesenchymal stem
cells deposited on the surface of this constructs enhance its osteogenic differentiation. In
this study the investigators seeds cultured bone marrow derived mesenchymal stem cells on
bone matrix, to evaluate its therapeutic potential in repairing unicameral or aneurysmal
bone cyst.This composite is placed in the bone cyst after its curettage during a
surgery.Post-operation assessment is done by X-Ray examination and MRI at 1, 2, 6, and 12
months after treatment.