Inclusion Criteria:

- Provision of informed consent

- Female or male aged 18 years and over

- Histologic or cytologic confirmation of advanced gastric cancer

- Stage III-IV (AJCC 7th)

- ECOG: 0-2

- Have tumor sample that can be tested for BRCA1 mRNA expression

- Negative pregnancy test for women of childbearing potential

- Neutrophile granulocyte greater than 1.5×10^9/L

- Hemoglobin greater than 10g/dL

- Platelet greater than 100×10^9/L

- Serum bilirubin not greater than 1.5x upper limit of reference range (ULRR)

- ALT or AST not greater than 1.5x ULRR

- Creatinine clearance no less than 60ml/min

Exclusion Criteria:

- Have at least another primary malignant tumor

- Active infection

- Chemotherapy with experimental drug within 3 weeks before the start of study therapy

- Women who are pregnant or breast feeding

- Weight loss greater 10% within 6 weeks before the start of study therapy